Dietary Supplementation of 25-hydroxycholecalciferol Increases Tibial Mass by Suppression Bone Resorption in Meat Ducks

Authors

• Huaiyong Zhang, Sichuan Agricultural University
• Qiufeng Zeng, Sichuan Agricultural University
• Shiping Bai, Sichuan Agricultural University
• Jianping Wang, Sichuan Agricultural University
• Xuemei Ding, Sichuan Agricultural University
• Yue Xuan, Sichuan Agricultural University
• Zhuowei Su, Sichuan Agricultural University
• Gergory S. Fraley, Hope College
• Bing Yao, Koninklijke DSM N.V.
• Keying Zhang, Sichuan Agricultural University

Document Type

Article

Publication Date

12-1-2020

Publication Source

Animal Nutrition

Volume Number

6

Issue Number

4

First Page

467

Last Page

479

ISSN

24056545

E-ISSN

24056383

Abstract

Leg problems often result from the rapid weight gain and poor bone quality in modern ducks, leading to a high risk of fractures and continuous pain. We hypothesized that improving bone quality in combination with delaying weight gain via a low nutrient density (LND) diet probably reverses these skeletal abnormalities. Studies indicated that 25-hydroxycholecalciferol (25-OH-D3), a vitamin D3 metabolite, is effective in treating bone-related disorders. Therefore, Exp. 1 evaluated the effects of 25-OH-D3 on tibial mass of meat ducks. Male meat ducklings were fed a standard nutrient density diet (containing a regular vitamin regimen) without or with 25-OH-D3 at 0.069 mg/kg for 35 d. The results showed that 25-OH-D3 supplementation improved the mineral content, microarchitecture and mechanical properties of tibias, and this companied by a decreased serum bone resorption marker and a concomitant decrement in osteoclast-specific marker genes expression. Subsequently, Exp. 2 was conducted to examine the impacts of 25-OH-D3 incorporating an LND diet on tibial quality of ducks under 2 different vitamin regimens (regular and high). Ducklings were allocated to a 2 × 2 factorial arrangement with 2 kinds of vitamin premixes and without or with 25-OH-D3 at 0.069 mg/kg in LND diets. The high premix had higher levels of all vitamins except biotin than the regular premix. The results demonstrated that high vitamin diets exhibited more significant effects than regular vitamin diets on inhibiting bone turnover and increasing minerals deposition. Tibial mineral content, microarchitecture, and strength of birds under the regular vitamin regimen were increased by 25-OH-D3 supplementation; However, these positive effects were not observed in ducks under the high vitamin regimen. To conclude, 25-OH-D3 supplementation improves tibial mass by suppressing osteoclast-mediated bone resorption in meat ducks, and this positive impact only was observed in regular but not high vitamin regimen when birds fed an LND diet.

Keywords

Bone turnover, Meat duck, Tibial mass, Vitamin, Vitamin D3 metabolites

Recommended Citation

Published in: Animal Nutrition, Volume 6, Issue 4, December 1, 2020, pages 467-479.