Nickel-Mediated Decarbonylative Cross-Coupling of Phthalimides with in Situ Generated Diorganozinc Reagents
Document Type
Article
Publication Date
5-6-2011
Publication Source
Journal of Organic Chemistry
Volume Number
76
Issue Number
9
First Page
3588
Last Page
3593
Publisher
American Chemical Society
ISSN
0022-3263
Abstract
The nickel-mediated cross-coupling of phthalimides with diorganozinc reagents proceeds via a decarbonylative process to produce ortho-substituted benzamides in high yields. In addition to tolerating diverse phthalimide functionality, including alkyl, aryl, and heteroatom containing substituents, this methodology proceeds smoothly with diorganozinc reagents prepared from aryl bromides and utilized without purification.
Recommended Citation
Published in: Journal of Organic Chemistry, Volume 76, Issue 9, May 6, 2011, pages 3588-3593. Copyright © 2011 American Chemical Society, Washington, DC. The final published version is available at: http://dx.doi.org/10.1021/jo200347j
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