Nickel-Mediated Decarbonylative Cross-Coupling of Phthalimides with in Situ Generated Diorganozinc Reagents

Document Type

Article

Publication Date

5-6-2011

Publication Source

Journal of Organic Chemistry

Volume Number

76

Issue Number

9

First Page

3588

Last Page

3593

Publisher

American Chemical Society

ISSN

0022-3263

Abstract

The nickel-mediated cross-coupling of phthalimides with diorganozinc reagents proceeds via a decarbonylative process to produce ortho-substituted benzamides in high yields. In addition to tolerating diverse phthalimide functionality, including alkyl, aryl, and heteroatom containing substituents, this methodology proceeds smoothly with diorganozinc reagents prepared from aryl bromides and utilized without purification.

Share

COinS