2-(3-arylacryloyl)-3-Methylquinoxaline 1,4-Dioxides as Potential Hypoxic Selective Cytotoxins

Authors

Kristin Dittenhafer, Hope CollegeFollow
Umashankar Das, University of Saskatchewan
Brent L. Younglove, Hope College
Hilary Mackay, Hope CollegeFollow
Toni Brown, Hope CollegeFollow
Jonathan R. Dimmock, University of Saskatchewan
Moses Lee, Hope CollegeFollow
Hari N. Pati, University of Saskatchewan

Document Type

Article

Publication Date

2008

Publication Source

HeterocyclicCommunications

Volume Number

14

Issue Number

5

First Page

385

Last Page

388

Publisher

Freund Publishing House Ltd.

ISSN

0793-0283

Abstract

The synthesis of a series of 2-(3-arylacryloyl)-3-methylquinoxaline 1,4-dioxides is reported. In-vitro cytotoxic activity of these compounds was evaluated via the MTT assay in B16 murine melanoma and L1210 murine leukemia cell lines. A dichloro analogue was found to be the most cytotoxic and was > 30-fold more active than the quinoxaline control (IC50 = 2 vs. 67 mu M in L1210, respectively). These results suggest that compounds containing two bioactive moieties could be developed as hypoxic selective cytotoxins.

Recommended Citation

Published in: HeterocyclicCommunications, Volume 14, Issue 5, January 1, 2008, pages 385-388. Copyright © 2008 Freund Publishing House Ltd., Tel Aviv, Israel. The final published version is available at: http://dx.doi.org/10.1515/HC.2008.14.5.385