Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: Cu-67
Document Type
Article
Publication Date
10-21-2014
Publication Source
Scientific Reports
Volume Number
4
Issue Number
6706
Publisher
Nature Publishing Group
ISSN
2045-2322
Abstract
The work presented here describes a proof-of-principle experiment for the chemical extraction of Cu-67 from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A Cu-67 beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88 +/- 3% and the radiochemical yield was >= 95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.
Keywords
Silica Production, Enriched Zn-70, Radioimmunotherapy, Antibody, Separation, System, Cu-67-2it-bat-lym-1, Cyclotron, Lymphoma, Design
Recommended Citation
Mastren, Tara, Aranh Pen, Graham F. Peaslee, Nick Wozniak, Shaun Loveless, Scott Essenmacher, Lee G. Sobotka, David J. Morrissey, and Suzanne E. Lapi. “Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu.” Scientific Reports 4 (October 21, 2014). doi:10.1038/srep06706.
