Mother’s own milk (MOM) reduces the risk of morbidities in very low birth weight (VLBW) infants. When MOM is unavailable, donor breastmilk (DM) is used, with unclear impact on short- and long-term growth. This retrospective analysis compared anthropometric data at six time points from birth to 20–24 months corrected age in VLBW infants who received MOM supplements of preterm formula (n = 160) versus fortified DM (n = 161) during neonatal intensive care unit (NICU) hospitalization. The cohort was 46% female; mean birth weight and gestational age (GA) were 998 g and 27.3 weeks. Multilevel linear growth models assessed changes in growth z-scores short-term (to NICU discharge) and long-term (post-discharge), controlling for amount of DM or formula received in first 28 days of life, NICU length of stay (LOS), birth GA, and sex. Z-scores for weight and length decreased during hospitalization but increased for all parameters including head circumference post-discharge. Short-term growth was positively associated with LOS and birth GA. A higher preterm formula proportion, but not DM proportion, was associated with slower rates of decline in short-term growth trajectories, but feeding type was unrelated to long-term growth. In conclusion, controlling for total human milk fed, DM did not affect short- or long-term growth.
human milk, breastfeeding, neonatal, donor milk, growth, very low birth weight
Repository citation: Hoban, Rebecca; Schoeny, Michael E.; Esquerra-Zwiers, Anita; Kaenkumchorn, Tanyaporn K.; Casini, Gina; Tobin, Grace; Siegel, Alan H.; Patra, Kousiki; Hamilton, Matthew; Wicks, Jennifer; Meier, Paula; and Patel, Aloka L., "Impact of Donor Milk on Short- and Long-Term Growth of Very Low Birth Weight Infants" (2019). Faculty Publications. Paper 1513.
Published in: Nutrients, Volume 11, Issue 2, January 22, 2019, pages 241-. Copyright © 2019 MDPI.
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Hoban, R.; Schoeny, M.E.; Esquerra-Zwiers, A.; Kaenkumchorn, T.K.; Casini, G.; Tobin, G.; Siegel, A.H.; Patra, K.; Hamilton, M.; Wicks, J.; Meier, P.; Patel, A.L. Impact of Donor Milk on Short- and Long-Term Growth of Very Low Birth Weight Infants. Nutrients 2019, 11, 241. https://doi.org/10.3390/nu11020241