Host Lipids in Positive-Strand RNA Virus Genome Replication

Zhenlu Zhang, Shandong Agricultural University; Virginia Tech
Guijuan He, Virginia Tech; Fujian Agriculture and Forestry University
Natalie A. Filipowicz, Hope College
Glenn Randall, The University of Chicago
George A. Belov, University of Maryland
Benjamin G. Kopek, Hope College
Xiafeng Wang, Virginia Tech

Copyright © 2019 Zhang, He, Filipowicz, Randall, Belov, Kopek and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

Zhang Z, He G, Filipowicz NA, Randall G, Belov GA, Kopek BG and Wang X (2019) Host Lipids in Positive-Strand RNA Virus Genome Replication. Front. Microbiol. 10:286.


Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.