Document Type

Article

Publication Date

2-26-2019

Publication Source

Frontiers in Microbiology

Volume Number

10

Issue Number

286

First Page

1

Last Page

18

Publisher

Frontiers Media SA

ISSN

1664-302X

Comments

Copyright © 2019 Zhang, He, Filipowicz, Randall, Belov, Kopek and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

Zhang Z, He G, Filipowicz NA, Randall G, Belov GA, Kopek BG and Wang X (2019) Host Lipids in Positive-Strand RNA Virus Genome Replication. Front. Microbiol. 10:286. https://doi.org/10.3389/fmicb.2019.00286.

Abstract

Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.

Keywords

lipid metabolism, phospholipids, membrane association, positive-strand RNA virus, viral RNA replication

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