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Copyright © 2019 Zhang, He, Filipowicz, Randall, Belov, Kopek and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

Zhang Z, He G, Filipowicz NA, Randall G, Belov GA, Kopek BG and Wang X (2019) Host Lipids in Positive-Strand RNA Virus Genome Replication. Front. Microbiol. 10:286.


Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.