Nickel-Catalyzed Direct Addition of Diorganozinc Reagents to Phthalimides: Selective Formation of Gamma-Hydroxylactams
Georg Thieme Verlag
The nickel-catalyzed addition of diorganozinc reagents to phthalimides proceeds with excellent selectivity to provide 3-substituted-3-hydroxyisoindolin-1-one products. These 3-hydroxy--lactams are produced cleanly in high yield with numerous examples of imide substitution and a broad range of diorganozinc reagents that are prepared and utilized without purification.
Imide, Catalysis, Lactams, Organometallic Reagents, Nickel, Radical Cyclization, Chilenine
Dennis, Joseph M., Catherine M. Calyore, Jessica S. Sjoholm, Patrick J. Lutz, Joseph J. Gair and Jeffrey B. Johnson. "Nickel-Catalyzed Direct Addition of Diorganozinc Reagents to Phthalimides: Selective Formation of Gamma-Hydroxylactams." Synlett 24, no. 19 (2013): 2567-2570.