Dr. Jeff Johnson, Chemistry
The activation and functionalization of carbon-carbon single bonds has proven difficult to achieve using traditional organic methods. Previous Johnson Lab projects have explored the use of rhodium catalysts to permit the selective activation and functionalization of carbon-carbon bonds in ketones. However, these reactions have required a nearby nitrogen atom, presumably to coordinate with the rhodium. Herein, we explore a new type of reaction in which the coordinating nitrogen is provided by reversible imine formation from a ketone and a primary amine. Efforts towards making this reaction more generalizable are currently underway.
Repository citation: Trentadue, Kathryn; DeGlopper, Kimberly; and Campbell, Meghan, "Rhodium-Catalyzed Carbon-Carbon Bond Activation and Functionalization Using Imine Reactions" (2017). 16th Annual Celebration of Undergraduate Research and Creative Performance (2017). Paper 70.
April 21, 2017. Copyright © 2017 Hope College, Holland, Michigan.