Faculty Mentor(s)

Dr. Jeffrey Johnson, Chemistry

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The development of nickel-mediated catalysis has progressed to the decarbonylation of phthalimides for cross-coupling with boronic acids to form ortho-substituted benzamides. The variables of the reaction are being manipulated to determine if the nickel can be used catalytically rather than stoichiometrically. In addition, many reactions produce a byproduct in which a carbon-hydrogen bond forms in the desired position of the boronic acid substituent, making isolation of the ortho-substituted benzamide through column chromatography difficult. The source of this byproduct—the reduction product—is still under investigation as the scope and isolation of the product is expanded.