Faculty Mentor(s)
Dr. Jeffrey Johnson, Chemistry
Document Type
Poster
Event Date
4-12-2024
Abstract
Transition metal-catalyzed cross-coupling reactions involving organic boronic acids are ubiquitous throughout organic synthesis. Despite the popularity of these methods, some boronic acids, such as those with 2-heteroaryl, 2-fluoroaryl, and cyclopropyl substituents, are incompatible, as these species decompose via protodeboronation prior to their incorporation into the desired reaction. To circumvent the protodeboronation process, the organometallic intermediates typically generated via catalyst transmetallation with a boronic acid can instead be generated via β-carbon elimination Efforts will focus on solving the so-called "2-pyridyl problem" and broadening the scope of known coupling partners in a Suzuki-like reaction, then systematically expand to include other palladium- and rhodium-catalyzed reactions with an array of coupling partners generated via β-carbon elimination.
Recommended Citation
Repository citation: Tyshka, Anna G.; King, Tyler J.; Day, Lucas D.; and Welsh, Timothy R., "Expanding the Use of Palladium-Catalyzed beta-Aryl Elimination Reactions" (2024). 23rd Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2024). Paper 84.
https://digitalcommons.hope.edu/curca_23/84
April 12, 2024. Copyright © 2024 Hope College, Holland, Michigan.
Comments
This work was supported by the Schaap Science Undergraduate Research Fund and by the National Science Foundation under Grant No. 1764118.