Dr. Jeffrey Johnson, Chemistry
Carbon-carbon bonds are known for their relative stability. Past research has shown that certain metal catalysts are capable of breaking carbon-carbon bonds when a chelating directing group is present in the molecule. Methods involved in carbon-carbon bond activation could be greatly expanded through the use of removable directing groups.
This work employs amides as removable directing groups. These rhodium-catalyzed reactions involve successful C–C bond activation of the amides followed by coupling with a variety of substrates including Michael acceptors, alkenes, and boronic acids. Ongoing studies are required to optimize the reaction, to explore the substrate scope, and to determine the mechanism.
Repository citation: Muckian, Claire; Hedrick, Greg; Vanden Akker, Jonathan; and Anderson, Constance B., "Rhodium-Catalyzed Carbon-Carbon Bond Activation Utilizing Removable Amide Directing Groups" (2020). 19th Annual Celebration of Undergraduate Research and Creative Activity (2020). Paper 15.
April 17, 2020. Copyright © 2020 Hope College, Holland, Michigan.