Faculty Mentor(s)

Dr. Jeffrey Johnson, Chemistry

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Carbon-carbon bonds are known for their relative stability. Past research has shown that certain metal catalysts are capable of breaking carbon-carbon bonds when a chelating directing group is present in the molecule. Methods involved in carbon-carbon bond activation could be greatly expanded through the use of removable directing groups.

This work employs amides as removable directing groups. These rhodium-catalyzed reactions involve successful C–C bond activation of the amides followed by coupling with a variety of substrates including Michael acceptors, alkenes, and boronic acids. Ongoing studies are required to optimize the reaction, to explore the substrate scope, and to determine the mechanism.


This material is based upon work supported by the National Science Foundation under Grant Nos. 1148719 and 1764118. This work is also supported by the Schaap Endowed Fund for Undergraduate Research, the Camille and Henry Dreyfus Foundation, and the Hope College Department of Chemistry.

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