Faculty Mentor(s)
Dr. Jeffrey Johnson, Chemistry
Document Type
Poster
Event Date
4-17-2020
Abstract
Carbon-carbon bonds are known for their relative stability. Past research has shown that certain metal catalysts are capable of breaking carbon-carbon bonds when a chelating directing group is present in the molecule. Methods involved in carbon-carbon bond activation could be greatly expanded through the use of removable directing groups.
This work employs amides as removable directing groups. These rhodium-catalyzed reactions involve successful C–C bond activation of the amides followed by coupling with a variety of substrates including Michael acceptors, alkenes, and boronic acids. Ongoing studies are required to optimize the reaction, to explore the substrate scope, and to determine the mechanism.
Recommended Citation
Repository citation: Muckian, Claire; Hedrick, Greg; Vanden Akker, Jonathan; and Anderson, Constance B., "Rhodium-Catalyzed Carbon-Carbon Bond Activation Utilizing Removable Amide Directing Groups" (2020). 19th Annual Celebration of Undergraduate Research and Creative Activity (2020). Paper 15.
https://digitalcommons.hope.edu/curca_19/15
April 17, 2020. Copyright © 2020 Hope College, Holland, Michigan.
Comments
This material is based upon work supported by the National Science Foundation under Grant Nos. 1148719 and 1764118. This work is also supported by the Schaap Endowed Fund for Undergraduate Research, the Camille and Henry Dreyfus Foundation, and the Hope College Department of Chemistry.