Nickel-Mediated Decarbonylative Cross-Coupling of Phthalimides with in Situ Generated Diorganozinc Reagents
Journal of Organic Chemistry
American Chemical Society
The nickel-mediated cross-coupling of phthalimides with diorganozinc reagents proceeds via a decarbonylative process to produce ortho-substituted benzamides in high yields. In addition to tolerating diverse phthalimide functionality, including alkyl, aryl, and heteroatom containing substituents, this methodology proceeds smoothly with diorganozinc reagents prepared from aryl bromides and utilized without purification.
Published in: Journal of Organic Chemistry, Volume 76, Issue 9, May 6, 2011, pages 3588-3593. Copyright © 2011 American Chemical Society, Washington, DC. The final published version is available at: http://dx.doi.org/10.1021/jo200347j