Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: Cu-67
The work presented here describes a proof-of-principle experiment for the chemical extraction of Cu-67 from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A Cu-67 beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88 +/- 3% and the radiochemical yield was >= 95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.
Mastren, Tara, Aranh Pen, Graham F. Peaslee, Nick Wozniak, Shaun Loveless, Scott Essenmacher, Lee G. Sobotka, David J. Morrissey, and Suzanne E. Lapi. “Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu.” Scientific Reports 4 (October 21, 2014). doi:10.1038/srep06706.