Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: Cu-67
Nature Publishing Group
The work presented here describes a proof-of-principle experiment for the chemical extraction of Cu-67 from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A Cu-67 beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88 +/- 3% and the radiochemical yield was >= 95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.
Silica Production, Enriched Zn-70, Radioimmunotherapy, Antibody, Separation, System, Cu-67-2it-bat-lym-1, Cyclotron, Lymphoma, Design
Mastren, Tara, Aranh Pen, Graham F. Peaslee, Nick Wozniak, Shaun Loveless, Scott Essenmacher, Lee G. Sobotka, David J. Morrissey, and Suzanne E. Lapi. “Feasibility of Isotope Harvesting at a Projectile Fragmentation Facility: 67Cu.” Scientific Reports 4 (October 21, 2014). doi:10.1038/srep06706.