Incorporation of Boronic Acids in Cross-Coupling Reactions Proceeding through C-C Activation
Dr. Jeffrey Johnson
Carbon-carbon single bonds can be difficult to activate due to their nonpolar and covalent nature. In recent years, the use of appropriate directing groups and transition metal catalysts has led to the activation and functionalization of carbon-carbon single bonds. Using quinolinyl ketones, our group has demonstrated the successful rhodium-catalyzed exchange of ketone substitution with alkyl and aryl boronic acids. The reaction proceeds in good to excellent yields with a broad range of functionality on both the quinolinyl ketones and the boronic acids.
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