The Effects of Directing Groups in Rhodium Catalyzed Decarbonylation Reactions
Dr. Jeffrey Johnson
The activation of carbon-carbon single bonds is a challenge due to the inherent strength of the bonds as a result of a lack of flexibility in the sigma bond and steric congestion that can occur around the bond. These bonds can be broken with the use of rhodium catalysts. A key reaction that can be carried out using carbon-carbon bond activation is the decarbonylation reaction. This occurs in the presence of both a rhodium catalyst and a nitrogen directing group. Herein we describe the synthetic pathways for starting materials, as well as the kinetic effects of various directing groups on the decarbonylation.
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