Incorporation of Boronic Acids in Cross-Coupling Reactions Proceeding through C-C Activation
Faculty Mentor(s)
Dr. Jeffrey Johnson
Document Type
Poster
Event Date
4-10-2015
Abstract
Continued exploration of the rhodium-catalyzed intramolecular carboacylation of quinolinyl ketones and tethered alkenes has prompted the investigation into intermolecular cross-coupling reactions. Proceeding through a similar intermediate generated from C-C bond activation, a variety of rhodium catalysts, directing moieties, and boron transmetallating reagents were screened in pursuit of the selective activation and functionalization of substituted ketones. Apart from investigating the functional group tolerance of the reaction, current work is being done to optimize reaction conditions as well to develop facile sp2-sp3 crosscoupling pathways of ketones with alkyl boron reagents.
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Comments
This research was supported by the Camille & Henry Dreyfus Foundation, Inc. and the National Science Foundation (CHE-1148719).