Carbon-Carbon Single Bond Activation Used for Coupling with Michael Acceptors
Dr. Jeffrey Johnson
Intramolecular alkene carboacylation has previously been achieved under rhodium catalysis using quinolinyl ketones. Utilizing insight gained from mechanistic studies, a series of new quinolinyl ketone substrates containing ortho-substitution have been prepared and subjected to rhodium catalysis in the presence of an exogenous alkene. This poster provides an overview of substrate synthesis as well as the unexpected product. Rather than the anticipated reaction sequence, these substrates have been observed to undergo carbon-carbon bond activation followed by conjugate addition to Michael acceptors.
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