Dr. Amanda Eckermann
Magnetic resonance imaging (MRI) is an important technique used throughout the medical field to gain improved clinical diagnostic ability. Often, different tissues can be weighted within the images if MRI contrast agents are used. Common clinical contrast agents use gadolinium to alter the T1 relaxation times of protons within surrounding tissues. Gadolinium(III), a lanthanide cation, has a grand seven unpaired electrons in its electronic configuration [Xe] 4f7. There are already a plethora of gadolinium chelate contrast agents available for medical use; however the sensitivity of these agents may be improved by increasing the rotational correlation time, tr. The goal of slower tumbling rates can be achieved by increasing their molecular weight. Thus, we propose attaching multiple gadolinium chelates to a central transition metal scaffold. The increase in molecular weight will alter the tr and improve the relaxation efficiency of the agent. These metal scaffolds will most likely include a Ru3O core.
Repository citation: SantaLucia, Daniel, "Transition Metal Scaffolds as MRI Contrast Agents" (2014). 13th Annual Celebration of Undergraduate Research and Creative Performance (2014). Paper 29.
April 11, 2014. Copyright © 2014 Hope College, Holland, Michigan.