Dr. Jeffery Johnson
Intramolecular alkene carboacylation has previously been achieved under rhodium catalysis using quinolinyl ketones. Utilizing insight gained from mechanistic studies, new substrates containing ortho-substitution have been prepared and subjected to rhodium catalysis with an exogenous alkene. This research provides an overview of substrate synthesis as well as the unexpected product—rather than the anticipated carboacylation these substrates have been observed to undergo carbon-carbon bond activation followed by conjugate addition to Michael acceptors.
Repository citation: Calyore, Catherine; Kirsch, Janelle; Phipps, Erik; and Johnson, Jeffery B., "Carbon-Carbon Single Bond Activation for Nucleophilic Addition to Michael Acceptors" (2014). 13th Annual Celebration of Undergraduate Research and Creative Performance (2014). Paper 28.
April 11, 2014. Copyright © 2014 Hope College, Holland, Michigan.