Investigation of Drug-Nanoparticle Interactions by Isothermal Titration Calorimetry
Dr. Michael Seymour; Dr. Jonathan Peterson
The widespread use of antibiotics and other drugs for human medicine and in animal agriculture has resulted in the contamination of soils and natural waters by these compounds. The adverse effects of antibiotic contaminants on indigenous microbial communities have generated interest in the fate and transport of these pharmaceuticals in natural soil-water systems. The role of mineral oxide nanoparticles, with their high surface area to volume ratio, could have significant impact on drug transport and removal mechanisms in groundwater environments. This study uses isothermal titration calorimetry (ITC) to evaluate the strength of binding between selected drugs and nanoparticles over a range of pH levels. Through careful control of the stoichiometry and reaction conditions, it will be possible to quantitatively evaluate the nature of these nanoparticle – drug interactions.
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