Thiophene­Substituted Porphyrins as Redox Mediators for Electrochemical Biosensors

Faculty Mentor(s)

Dr. Elizabeth Sanford, Hope College
Dr. Kenneth Brown, Hope College

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Electrochemical biosensors are instruments that use molecular recognition components such as enzymes to selectively detect biomolecules through a mechanism involving the transduction of a signal from an electron transfer reaction. In such a system it is necessary for multiple layers of a device to communicate the electron transfer reaction from the layer in which it occurs to the electrode. For this communication to occur well, a redox mediator is typically needed between the enzyme layer and the electrode. This work describes the preparation of thiophene substituted porphyrins that are then polymerized on electrodes to provide a communication or redox mediation layer between an enzyme and electrode.

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