Preparation of Ferrocene-Based Redox Mediators for Use in Glucose Sensors

Faculty Mentor(s)

Dr. Elizabeth Sanford, Hope College
Dr. Kenneth Brown, Hope College

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Diabetes is a disease that affects millions of Americans and is a major health concern for our country. It is characterized by the body's inability to properly use insulin to regulate blood glucose levels. To control their diabetes medically, patients must monitor blood glucose levels using an internal or external glucose sensor. The goal of this research is to improve the sensitivity and quality of these devices by preparing novel redox mediators that can be electropolymerized on the surface of electrodes used in glucose sensors. The redox mediators join a ferrocene to a thiophene so that the iron-­based ferrocene, responsible for the redox chemistry, can be attached to an electrode via the thiophene portion. The synthesis, electropolymerization, and characterization by cyclic voltammetry of these compounds is presented as well as initial glucose sensing studies.

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